VITAMIN E ACETATE

PRODUCT IDENTIFICATION
CAS NO.

7695-91-2

VITAMIN E ACETATE

EINECS NO. 231-710-0
FORMULA

C31H52O3

MOL WT.

472.75

H.S. CODE

  

TOXICITY

 
SYNONYMS

DL-alpha-Tocopheryl Acetate;

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-b- enzopyran-6-ol, acetate; Tocopheryl acetate; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate; 133-80-2; 1407-18-7; 18920-61-1; 54-22-8; DL-alpha tocopheryl acetate;
SMILES Acetic Acid Ester of DL-alpha-Tocopherol

CLASSIFICATION

VITAMINS /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE Clear to yellow viscous oil
MELTING POINT  
BOILING POINT

 

SPECIFIC GRAVITY

 

SOLUBILITY IN WATER

Insoluble

SOLVENT SOLUBILITY

Miscible with hydrocarbons, alcohols, fats and oils

pH  
VAPOR DENSITY

 

FLASH POINT

 

APPLICATIONS
Tocopherol is a a fat-soluble vitamin. Vitamin E refers to a family of at least eight molecules having a biological antioxidant activity and a structure of chromanol ring substituted by an aliphatic side chain (C-12) containing two methyl groups in the middle and two more at the terminal position. Chromanol ring have a hydroxyl group which will reduce free radicals by the donation of a hydrogen atom. The side chain is hydrophobic so that the molecules can penetrate into biological membranes. Vitamin E exists in eight different forms or isomers, four tocopherols and four tocotrienols. Tocopherol and tocotrienol are distinguished by the saturatation of side chain; the side chain of four tocopherols are saturated, whereas the four tocotrienols' side chains contain three double-bonds, which are adjoined with a methyl group. The four tocopherols and the four tocotrienols have an alpha, beta, gamma and delta form determined by the number of methyl groups on the chromanol ring. The alpha form has three methyl groups, the beta and gamma forms have two methyl groups and the delta form has only one. Each form has its own biological activity. Alpha-tocopherol is recognized as the most effective biological antioxidant. Tocotrienols have more antioxidant potency than tocopherols, but human can digest tocotrienols poorly and eliminates rapidly from the body. Tocotrienols are absorbed by the skin and thus are used as an ingredient in a cream. Vitamin E is used in as an moisturizing agent, an antioxidant and to improve the elasticity of the skin in cosmetics and skin care products, hair care and sun screening products. 

Members of tocopherol products

Product

CAS RN
D-gamma-Tocopherol 54-28-4
D-alpha-tocopheryl acetate 58-95-7
Vitamin E 59-02-9
Retinaldehyde 116-31-4
delta-Tocopherol 119-13-1
beta-Tocopherol 148-03-8
beta-Tocotrienol 490-23-3
Methyltocols 1406-66-2
alpha-Tocotrienol 1721-51-3
alpha-Tocopherol dimer 2896-55-1
Tocopheronolactone 3121-68-4

D-alpha-Tocopherol succinate

4345-03-3
gamma-Tocotrienol 4382-43-8
N-Methyl alpha-tocopheramine 4869-06-1
Tocotrienol 6829-55-6
Tocopherylquinone 7559-04-8
beta-Tocopheramine 7591-11-9
gamma-Tocopherol 7616-22-0
alpha-Tocopheramine 7666-00-4
Vitamin E acetate 7695-91-2
alpha-Tocopherol dimer 7718-59-4
Aescorin 8054-09-9
alpha-Tocopheryl polyethylene glycol succinate 9002-96-4

DL-alpha-tocopherol

10191-41-0
DL-alpha-Tocopheryl calcium succinate 14464-85-8
Tocopherol calcium succinate 14638-18-7
alpha-Tocopherol quinol 14745-36-9
Vitamin E succinate 17407-37-3
delta-Tocopheramine 18230-02-9
Tocotrienol, delta 25612-59-3
Tocophersolan 30999-06-5
Tocopheryl linoleate 36148-84-2
alpha-Tocopherol phosphate 38976-17-9
Tocopheryl retinoate 40516-49-2
Tocopheryl nicotinate 43119-47-7
5-Nicotinooxymethyl-alpha-tocopherylnicotinate 51605-68-6
DL-alpha-Tocopherol nicotinate 51898-34-1
Vitamin E acetate DL-form 52225-20-4

DL-alpha-Tocopherol phosphate disodium salt

60934-46-5
8-Hydroperoxytocopherone 67353-73-5
Vitamin A, vitamin E mixture 70713-06-3
N-Methyl-alpha-tocopheramine nitroxide 78249-60-2
Chlorinated alpha-tocopherol 80040-98-8
DL-alpha-Tocopheryl 5-butylpicolinate 85446-70-4
DL-alpha-Tocopheryl 5-(3,4-dibromobutyl)picolinate 85446-72-6
DL-alpha-Tocopheryl 5-(3,4-dichlorobutyl)picolinate 85446-73-7
DL-alpha-Tocopheryl 5-(4-bromobutyl)picolinate 85446-74-8
DL-alpha-Tocopheryl 5-benzylpicolinate 85446-76-0
DL-alpha-Tocopheryl 5-benzyloxypicolinate 85446-77-1
DL-alpha-Tocopheryl 5-(4-chlorobutyloxy)picolinate 85446-82-8
DL-alpha-Tocopheryl 5-(4-chlorophenyloxy)picolinate 85446-83-9
DL-alpha-Tocopheryl 5-butylthiopicolinate 85446-84-0
DL-alpha-Tocopheryl 5-(3-chloropropylthio)picolinate 85446-89-5
DL-alpha-Tocopheryl 5-(2-propenyl)thiopicolinate 85446-90-8
N-4-Azido-2-nitrophenyl-beta-alanyl-gamma-tocopherol 99332-97-5
Tocopheroxy radical 113085-06-6
8-((2,4-Dimethyl-1-nitrilopent-2-yl)dioxy)tocopherone 123438-35-7
L-Ascorbic acid DL-alpha-tocopherol phosphoric diester potassium salt 127061-56-7
Epoxytocopherone 128442-18-2
L-Ascorbic acid DL-alpha-tocopherol phosphoric diester sodium salt 132746-07-7
1-Thio-alpha-tocopherol 133869-30-4
8a-Hydroperoxy-tocopherone 141913-27-1
SALES SPECIFICATION

BIBLIOGRAPHY

USP / FCC

APPEARANCE

 Clear to yellow viscous oil

ASSAY (VITAMIN E)

96.0 - 102% (per USP)

IDENTIFICATION

Passes Test ( per USP)

ACID VALUE

 2.0 max ( KOH mg / g)

ABSORPTIVITY

7.5-9 (254 nm) / 42-45 (284 nm) in Ethanol

SULPHATED ASH

0.1% max

HEAVY METALS

10ppm max

ARSENIC

3ppm max

LEAD

10ppm max

COPPER AND ZINC

50ppm max

VOLATILE IMPURITIES

Passes Test

FREE TOCOPHEROL

1.0% max
TRANSPORTATION
PACKING
190kgs in Drum
HAZARD CLASS  
UN NO.  

GENERAL DESCRIPTION OF ANTIOXIDANT
In industrial process, the term antioxidant refers to a chemical substance that are added to prevent or delay deteriorations by the consumption of molecular oxygen in the air, such as corrosion inhibition of metals, explosions, rubber vulcanization, anti-knocking internal combustion, preservative of paints, vegetable oils, and prepared foods. in biology, antioxidants act to protect cells against free radicals. Free radicals play an important role in a number of biological processes such as the intracellular killing of bacteria by neutrophil granulocytes and certain cell signalling processes. However, because of their reactivity, free radicals can cause side reactions resulting in cell damage, which may contribute to the development of cardiovascular disease and cancer. Lipids, protein and nucleic acids are weak to free radicals. Free radicals may be involved in the mechanisms of aging itself also. The body has a number of mechanisms to minimize free radical induced damage and to repair damage.  Antioxidant enzymes produced in the body play a key role in these defense mechanisms, such as glutathione peroxidase, glutathione reductase, catalase, thioredoxin reductase and superoxide dismutase. Additionally, chemical antioxidants neutralize free radicals by accepting or donating an electron to eliminate the unpaired condition. These antioxidants include three vitamins (vitamin A, vitamin C and vitamin E), polyphenols, bilirubin and uric acid. Synthetic or natural antioxidants are widely used in nutrition and medicine and prepared foods for the effect to slow down the natural aging process and to prevent or delay certain diseases that result from cellular damage. But there should be considerable researches whether antioxidant supplementation provide beneficial effect, and if so, which and what amount of antioxidants are optimal. There are hundreds of different types of nutritional antioxidants include vitamins, coenzymes, selenium, minerals, hormones, carotenoids, non-carotenoid terpenoids, flavonoids (flavonols, flavones isoflavones, flavanols,, anthocyanidins), nonflavonoid phenolics, polyphenolics and their esters (ellagic acids, citric acids, uric acids, gallic acids, salicylic acids, rosmarinic acids, cinnamic acids, chlorogenic acids, chicoric acids)